Lembu Road will be converted temporarily to a one-way traffic street with effect from Wednesday at 6am.
This is to facilitate drainage improvement work along Syed Alwi Road.
PUB says the drainage work is part of the national water agency's efforts to increase flood protection in the area.
PUB says two-way traffic on Lembu Road will be restored by the end of third quarter 2013.
Motorists are advised to use Desker Road to access Lembu Road during this period.